منابع مشابه
Metabolic engineering.
Metabolic engineering is the science that combines systematic analysis of metabolic and other pathways with molecular biological techniques to improve cellular properties by designing and implementing rational genetic modifications. As such, metabolic engineering deals with the measurement of metabolic fluxes and elucidation of their control as determinants of metabolic function and cell physio...
متن کاملMetabolic engineering
MetaCyc database http://metacyc.org/ MetaCyc is a database of metabolic pathways containing more than 1400 pathways from more than 1800 organisms. KEGG pathway database http://www.genome.jp/kegg/pathway.html The KEGG pathway database consists of a collection of manually-curated metabolic maps with connections to metabolite, enzyme and organismal data. KEGG also contains tools for reconstructing...
متن کاملGenetic-Metabolic Coupling for Targeted Metabolic Engineering.
Production of chemicals in microbes often employs potent biosynthetic enzymes, which can interact with the microbial native metabolism to affect cell fitness and product yield. However, production optimization largely relies on data collected from wild-type strains in the absence of metabolic perturbations, thus limiting their relevance to specific conditions. Here, we address this issue by cou...
متن کاملMetabolic Engineering of Bacteria
Metabolic glycoengineering is a technique introduced in the early 90s of the last century by Reutter et al.. It utilises the ability of cells to metabolically convert sugar derivatives with bioorthogonal side chains like azides or alkynes and by that incorporation into several glyco structures. Afterwards, the carbohydrates can be labelled to study their distribution, dynamics and roles in diff...
متن کاملAnalytics for Metabolic Engineering
Realizing the promise of metabolic engineering has been slowed by challenges related to moving beyond proof-of-concept examples to robust and economically viable systems. Key to advancing metabolic engineering beyond trial-and-error research is access to parts with well-defined performance metrics that can be readily applied in vastly different contexts with predictable effects. As the field no...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2000
ISSN: 1087-0156,1546-1696
DOI: 10.1038/73665